Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery
نویسندگان
چکیده
The objective of the present study was to develop n-propyl gallate-loaded solid lipid nanoparticles (PG-SLNs) in a hydrogel (HG) formulation using Transcutol-P (TC-P) as permeation enhancer. Modified solvent injection technique applied produce optimized PG-SLNs via Quality by Design approach and central composite design. vitro mucoadhesion, scavenging activity, drug release, studies PG from PG-SLNs-loaded HG were evaluated under simulated nasal conditions. Compared with release behavior SLNs, showed lower burst effect sustained profile. cumulative TC-P 600 μg/cm2 within 60 min, which is 3–60-fold higher than native PG, respectively. Raman mapping that distribution more concentrated having concentrations hyaluronic acid. assay demonstrated increased antioxidant activity at HG. Due enhanced stability mucoadhesive properties, developed HG-based SLNs can improve absorption increasing residence time on mucosa. This provides proof potential combining advantages for intranasal delivery antioxidants.
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2021
ISSN: ['1424-8247']
DOI: https://doi.org/10.3390/ph14070696